Unexpected enrichment of DNA aptamers for Zn<sup>2+</sup> ions from an insulin selection
Yibo Liu, Xiaoqin Wang, Juewen Liu
Abstract
With an effort to select for DNA aptamers that can bind to insulin, Zn 2+ -binding aptamers were obtained instead. The Zn-1 aptamer showed 450-fold selectivity towards Zn 2+ compared to Cd 2+ .
Topics & Concepts
AptamerDissociation constantChemistryDNASelectivityBinding selectivityInsulinDissociation (chemistry)Combinatorial chemistryBiophysicsBiochemistryMolecular biologyBiologyReceptorPhysical chemistryCatalysisEndocrinologyAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryRNA Interference and Gene Delivery