Pyrimethamine conjugated histone deacetylase inhibitors: Design, synthesis and evidence for triple negative breast cancer selective cytotoxicity
Bocheng Wu, Shaghayegh Fathi, Shanee Mortley, Mahir Mohiuddin, Young C. Jang, Adegboyega K. Oyelere
Topics & Concepts
Histone deacetylaseChemistrySTAT3VorinostatHistone deacetylase inhibitorCancer researchSTAT proteinTriple-negative breast cancerCytotoxicityCell cultureHDAC1HistoneSignal transductionBreast cancerBiologyIn vitroCancerBiochemistryGeneGeneticsHistone Deacetylase Inhibitors ResearchSynthesis and biological activityCancer Mechanisms and Therapy