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RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth

Jing He, Aoxue Wang, Qin Zhao, Yejun Zou, Zhuo Zhang, Nannan Sha, Guofang Hou, Bei Zhou, Yi Yang, Tao Chen, Yuzheng Zhao, Yuhui Jiang

2024Nature Structural & Molecular Biology15 citationsDOI

Topics & Concepts

RegulatorRedoxNAD+ kinaseRNA interferencePyrimidineChemistryCell biologyNegative regulatorBiochemistryBiologyRNASignal transductionGeneEnzymeOrganic chemistryBiochemical and Molecular ResearchCancer, Hypoxia, and MetabolismRNA modifications and cancer
RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth | Litcius