Prevalence and risk analysis of mobile colistin resistance and extended-spectrum <i>β</i> -lactamase genes carriage in pet dogs and their owners: a population based cross-sectional study
Lei Lei, Yongqiang Wang, Junjia He, Chang Cai, Qingzhi Liu, Dawei Yang, Zhiyu Zou, Lingyu Shi, Jianqin Jia, Yang Wang, Timothy R. Walsh, Jianzhong Shen, Yougang Zhong
Abstract
Mobile colistin resistance gene mcr-1 and extended-spectrum β-lactamase gene blaCTX-M are highly prevalent in human – and pet-derived bacteria. Isolation of identical strains of mcr-1-positive Escherichia coli (MCRPEC) or blaCTX-M-positive E. coli (CTX-MPEC) from pets and humans highlighted the potential for co-colonization of antibiotic-resistant bacteria which can be a risk for dissemination of resistance genes. In this study, the prevalence of mcr-1 and blaCTX-M carriage from rectal swabs in 299 families (dogs and their owners) were 2.7 and 5.3%, respectively. We identified a significant association of mcr-1 carriage between dogs and their owners. Whilst antibiotic use in the previous three months was associated with blaCTX-M carriage in dogs. Only one instance of dog and owner carrying identical CTX-MPEC was observed. Although the prevalence of identical strains in one family is rare, the huge number of dog ownership worldwide suggest that this threat should not be underestimated.