Characterization of the endoplasmic reticulum–resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding
Shingo Kanemura, Elza Firdiani Sofia, Naoya Hirai, Masaki Okumura, Hiroshi Kadokura, Kenji Inaba
Abstract
-dependent PDI oxidase in cells, whereas PDI oxidation may not be the central physiological role of human GPx8.
Topics & Concepts
Endoplasmic reticulumOxidative phosphorylationOxidative foldingFolding (DSP implementation)Oxidative stressProtein foldingPeroxidaseBiochemistryChemistryCell biologyBiologyEnzymeProtein disulfide-isomeraseEngineeringElectrical engineeringRedox biology and oxidative stressEndoplasmic Reticulum Stress and DiseaseNeutrophil, Myeloperoxidase and Oxidative Mechanisms