Cellular and Extracellular Vesicle RNA Analysis in the Global Threat Fungus <i>Candida auris</i>
Isadora Filipaki Munhoz da Rocha, Sharon T. Martins, Rafaela F. Amatuzzi, Daniel Zamith‐Miranda, Joshua D. Nosanchuk, Márcio L. Rodrigues, Lysangela R. Alves
Abstract
Candida auris, a relevant emerging human-pathogenic yeast, is the first fungus to be called a global public health threat by the WHO. This is because of its rapid spread on all inhabited continents, together with its extremely high frequency of drug and multidrug resistance. In our study, we generated a large data set for 3 distinct strains of C. auris and obtained cellular small RNA fraction as well as extracellular vesicle RNA (EV-RNA) during normal growth conditions and after treatment with caspofungin, the first-line drug used to treat C. auris infection.
Topics & Concepts
Candida aurisFungusBiologyMicrobiologyPathogenic fungusMultiple drug resistanceDrug resistanceAntifungalBotanyFungal Infections and StudiesAntifungal resistance and susceptibilityInfective Endocarditis Diagnosis and Management