Mesoporous silica coated CeO<sub>2</sub> nanozymes with combined lipid-lowering and antioxidant activity induce long-term improvement of the metabolic profile in obese Zucker rats
Marina Parra‐Robert, Muling Zeng, Ying Shu, Guillermo Fernández‐Varo, Meritxell Perramón, Diti Desai, Junhao Chen, Dongdong Guo, Xu Zhang, Manuel Morales‐Ruiz, Jessica M. Rosenholm, Wladimiro Jiménez, Víctor Puntes, Eudald Casals, Gregori Casals
Abstract
maximized its cell antioxidant protective effects and minimized non-hepatic biodistribution. The one-pot synthesis method for the nanocomposite fabrication is implemented entirely in aqueous solution, room temperature and open atmosphere conditions, favoring scalability and offering a safe and translatable lipid-lowering and antioxidant nanomedicine to treat metabolic comorbidities associated with obesity. This approach may be further applied to address other metabolic disorders related to hyperlipidemia, low-grade inflammation and oxidative stress.