Chronic allergen exposure drives accumulation of long-lived IgE plasma cells in the bone marrow, giving rise to serological memory
Seblewongel Asrat, Navneet Kaur, Xia Liu, Li‐Hong Ben, Daisuke Kajimura, Andrew Murphy, Matthew A. Sleeman, André Limnander, Jamie Orengo
Abstract
bone marrow plasma cells arise during chronic allergen exposure and establish serological memory in both mice and humans.
Topics & Concepts
SerologyImmunologyImmunoglobulin EAllergenBone marrowBiologyAntibodyMedicineAllergyAsthma and respiratory diseasesAllergic Rhinitis and SensitizationMast cells and histamine