Design, Synthesis, Analysis, Evaluation of Cytotoxicity Against MCF-7 Breast Cancer Cells, 3D QSAR Studies and EGFR, HER2 Inhibition Studies on Novel Biginelli 1,4-Dihydropyrimidines
Namburu Lalitha Naishima, Syed Faizan, Ruby Mariam Raju, Aki Satya Venkata Lakshmi Sruthi, Veena NG, Gyanedra Kumar Sharma, Kumar S Vasanth, Vasanth Kumar Shivaraju, Ramith Ramu, B. R. Prashantha Kumar
Topics & Concepts
CytotoxicityChemistryLapatinibQuantitative structure–activity relationshipMCF-7Epidermal growth factor receptorCytotoxic T cellEGFR inhibitorsPharmacologyMTT assayBreast cancerStereochemistryIn vitroCancerCancer researchBiochemistryReceptorHuman breastInternal medicineTrastuzumabBiologyMedicineMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis of Tetrazole Derivatives