Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter
Agnese De Mario, Anna Tosatto, Julia M. Hill, János Kriston-Vizi, Robin Ketteler, Denis Vecellio Reane, Gino Cortopassi, György Szabadkai, Rosario Rizzuto, Cristina Mammucari
Abstract
uptake in cancer progression. Overall, we identify amorolfine and benzethonium as effective MCU-targeting drugs applicable to a wide array of experimental and disease conditions.
Topics & Concepts
MitochondrionRanolazineUniporterDrug discoveryBiologyCell biologyPharmacologyChemistryBiochemistryCytosolEnzymeMitochondrial Function and PathologyATP Synthase and ATPases ResearchNeuroscience and Neuropharmacology Research