Structural- and Site-Specific <i>N-</i>Glycosylation Characterization of COVID-19 Virus Spike with StrucGP
Bojing Zhu, Zexuan Chen, Jiechen Shen, Yintai Xu, Rongxia Lan, Shisheng Sun
Abstract
glycans as detected in previous studies, many uncommon glycosylation structures such as LacdiNAc structures, Lewis structures, Mannose 6-phosphate (M6P) residues, and bisected core structures were unambiguously mapped at a total of 20 glycosites in the S protein trimer and protomer. These data further support the glycosylation structural-functional investigations of the COVID-19 virus spike.
Topics & Concepts
GlycosylationChemistryGlycoproteomicsGlycanGlycoproteinTrimerComputational biologyBiochemistryBiologyDimerOrganic chemistrySARS-CoV-2 and COVID-19 ResearchBacteriophages and microbial interactionsBacterial Infections and Vaccines