Dissolving microneedle-encapsulated drug-loaded nanoparticles and recombinant humanized collagen type III for the treatment of chronic wound <i>via</i> anti-inflammation and enhanced cell proliferation and angiogenesis
Linyu Long, Wenqi Liu, Li Li, Cheng Hu, Shuyi He, Lu Lu, Jian Wang, Li Yang, Yunbing Wang
Abstract
using the diabetic rat full-thickness skin wound model. These results illustrated that the prepared MN could accelerate wound closure by reducing the inflammatory response and enhancing angiogenesis or collagen deposition, indicating their significant application value in wound dressings for chronic wound repair.
Topics & Concepts
Wound healingHyaluronic acidAngiogenesisPLGAChronic woundInflammationIn vivoAdhesionCell adhesionPharmacologyFibrosisMedicineBiocompatibilityBiomedical engineeringMaterials scienceChemistryCancer researchSurgeryNanoparticlePathologyNanotechnologyImmunologyBiologyAnatomyComposite materialMetallurgyBiotechnologyWound Healing and TreatmentsAdvancements in Transdermal Drug DeliveryTendon Structure and Treatment