N-substituted benzimidazole acrylonitriles as in vitro tubulin polymerization inhibitors: Synthesis, biological activity and computational analysis
Nataša Perin, Lucija Hok, Anja Beč, Leentje Persoons, Els Vanstreels, Dirk Daelemans, Robert Vianello, Marijana Hranjec
Topics & Concepts
ChemistryBenzimidazoleStereochemistryBiological activityTubulinMicrotubule polymerizationAcrylonitrilePolymerizationIn vitroCombinatorial chemistryMicrotubuleBiochemistryOrganic chemistryPolymerCell biologyBiologyCopolymerSynthesis and biological activityClick Chemistry and ApplicationsSynthesis and Characterization of Heterocyclic Compounds