Phenotypic instability of Mycobacterium tuberculosis strains harbouring clinically prevalent drug-resistant mutations
Yiwang Chen, Howard Takiff, Qian Gao
Abstract
Whole-genome sequencing (WGS) has shown great potential in the rapid diagnosis of drug-resistant tuberculosis;1,2 however, the discrepancies between WGS-based drug susceptibility testing (DST) and phenotypic DST have not been well characterised due to a scarcity of high-quality phenotypic DST data. Recently, the largest, globally sourced dataset of Mycobacterium tuberculosis strains with WGS data and phenotypic DST data was generated by WHO,3,4 providing a valuable and comprehensive resource for studying discrepancies between genotypic and phenotypic DST in detail.
Topics & Concepts
Mycobacterium tuberculosisTuberculosisDrug resistancePhenotypeGenotypeBiologyGeneticsMicrobiologyMedicineGenePathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisCancer therapeutics and mechanisms