Dialdehyde pectin-crosslinked and hirudin-loaded decellularized porcine pericardium with improved matrix stability, enhanced anti-calcification and anticoagulant for bioprosthetic heart valves
Mengyue Hu, Peng Xu, Zhao Yang, Xiaoshuang Yu, Xiaoshuang Yu, Can Cheng, Xixun Yu, Xixun Yu
Abstract
results revealed that the AP + Hirudin-PP specimens recruited the minimum immune cells in the implantation experiment, and also presented an excellent anti-calcification effect. Overall, AP + Hirudin-PP was endowed with competitive collagen stability (compared with GA-fixed PP), excellent hemocompatibility, good HUVECs-cytocompatibility, low immunogenicity and outstanding anti-calcification, suggesting that AP + Hirudin-PP might be a promising alternative to GA-fixed PP and exhibited a bright prospect in the clinical applications of BHVs.
Topics & Concepts
HirudinCalcificationDecellularizationChemistryHeart valveBiocompatibilityGlutaraldehydeBiomedical engineeringMaterials scienceBiophysicsBiochemistryThrombinSurgeryMedicinePlateletImmunologyExtracellular matrixPathologyBiologyChromatographyOrganic chemistryElectrospun Nanofibers in Biomedical ApplicationsCardiac Valve Diseases and TreatmentsTissue Engineering and Regenerative Medicine