Successful treatment of metastatic refractory gestational choriocarcinoma with pembrolizumab: A case for immune checkpoint salvage therapy in trophoblastic tumors
Kiran Clair, Nicolas Gallegos, Robert E. Bristow
Abstract
•Cure rates are high for choriocarcinoma, however chemoresistant disease often leads to death.•High expression of PD-L1 suggests a role for checkpoint inhibitors in choriocarcinoma.•Pembrolizumab should be considered for salvage therapy for chemoresistant choriocarcinoma.
Topics & Concepts
PembrolizumabChoriocarcinomaMedicineSalvage therapyRefractory (planetary science)OncologyImmune checkpointGestational trophoblastic diseaseChemotherapyInternal medicineImmunotherapyCancer researchPregnancyCancerGestationBiologyGeneticsAstrobiologyGestational Trophoblastic Disease StudiesPrenatal Screening and DiagnosticsCongenital Diaphragmatic Hernia Studies