LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development
Stephanie L. Pollitt, Kenneth R. Myers, Jin Yoo, James Q. Zheng
Abstract
homologue Lasp from a subset of commissural neurons in the developing ventral nerve cord produces defasciculated axon bundles that do not reach their targets. Together, our data support a novel role for LASP1 in actin-based lamellipodial protrusion and establish LASP1 as a positive regulator of both in vitro and in vivo axon development.
Topics & Concepts
BiologyLamellipodiumAxonCell biologyAxon guidanceActinSH3 domainGrowth coneHippocampal formationNeurosciencePhosphorylationCytoskeletonProto-oncogene tyrosine-protein kinase SrcGeneticsCellCellular Mechanics and InteractionsCardiomyopathy and Myosin StudiesConnective tissue disorders research