Cloning, purification, kinetic and anion inhibition studies of a recombinant β-carbonic anhydrase from the Atlantic salmon parasite platyhelminth <i>Gyrodactylus salaris</i>
Ashok Aspatwar, Harlan Barker, Heidi Aisala, Ksenia J. Zueva, Marianne Kuuslahti, Martti Tolvanen, Craig R. Primmer, Jaakko Lumme, Alessandro Bonardi, Amit Tripathi, Seppo Parkkila, Claudiu T. Supuran
Abstract
of 6.2 µM) showed a rather efficient inhibitory action. There are currently very few non-toxic agents effective in combating this parasite. GsaCAβ is subsequently proposed as a new drug target for which effective inhibitors can be designed.
Topics & Concepts
Enzyme kineticsCarbonic anhydraseEnzymeSulfamideRecombinant DNABiochemistryChemistryBiologyParasite hostingActive siteGeneOrganic chemistryComputer scienceWorld Wide WebEnzyme function and inhibitionPhenothiazines and Benzothiazines Synthesis and ActivitiesSynthesis and Catalytic Reactions