Erxian decoction inhibits apoptosis by activating Akt1 and repairs spinal cord injury in rats
Erliang Li, Rongbao Yan, Kang Yan, Ruqin Huang, Rui Zhang, Yanhua Wen, Shuang Li, Peng Li, Qiong Ma, Bo Liao
Abstract
Objective: Spinal cord injury (SCI) often leads to severe physiological and pathological changes in patients. Erxian Decoction (EXD) is effective in the postoperative treatment of spinal cord injury, but its specific mechanism of action is poorly defined. Methods: study, the rats were pretreated with or without EXD (5.76 g/kg, by intragastric gavage). Multiple molecular biological test methods to identify molecular mechanisms. One-way analysis of variance (ANOVA) was used with Bonferroni's post-hoc test to identify the differences between groups. Results: < 0.0001). Conclusions: EXD inhibits apoptosis by activating Akt1, reduce spinal cord edema and restore behavioral function after SCI in rats.