Dilated cardiomyopathy impairs mitochondrial biogenesis and promotes inflammation in an age- and sex-dependent manner
Maria Luisa Barcena, Sofya Pozdniakova, Natalie Haritonow, Pavelas Breiter, Anja A. Kühl, Hendrik Milting, István Baczkó, Yury Ladilov, Vera Regitz‐Zagrosek
Abstract
) was only detected in old DCM patients, suggesting that age has a greater effect than DCM on these alterations. Finally, an increased expression of inflammatory markers in older, failing hearts, with a stronger pro-inflammatory response in men, was observed. Together, these findings indicate that age- and sex-related increased inflammation and disturbance of mitochondrial homeostasis occurs in male individuals with DCM.
Topics & Concepts
Mitochondrial biogenesisInflammationSOD2Dilated cardiomyopathyInternal medicineDownregulation and upregulationEndocrinologyCardiomyopathyMedicineAMPKMitochondrionAgeingBiologyHeart failureCell biologyPhosphorylationOxidative stressGeneGeneticsProtein kinase ASuperoxide dismutaseMitochondrial Function and PathologyAutophagy in Disease and TherapyRNA modifications and cancer