Magnesium ascorbyl phosphate vesicular carriers for topical delivery; preparation, in-vitro and ex-vivo evaluation, factorial optimization and clinical assessment in melasma patients
Soha M. Kandil, Iman I. Soliman, Heba M. Diab, Nermeen Ibrahim Bedair, Marwa H. Mahrous, Ebtsam M. Abdou
Abstract
camera. The optimized ethosomal and niosomal gels showed comparable controlled permeation and higher skin retention over their ethosomes and niosomes formulations respectively. Magnesium ascorbyl phosphate ethosomal gel showed clinically and statistically significant melanin level decrease after one month while MAP niosomal gel showed clinically and statistically significant melanin level decrease after six months. A combination of MAP ethosomes and niosomes could be promising skincare formulations for melasma and hyperpigmentation short and long-term treatment.
Topics & Concepts
NiosomeAscorbic acidPermeationFactorial experimentPulmonary surfactantChromatographyMelasmaChemistryZeta potentialLiposomeAcneMaterials scienceMedicineDermatologyMembraneVesicleBiochemistryFood scienceNanotechnologyNanoparticleMathematicsStatisticsDermatologic Treatments and ResearchAdvancements in Transdermal Drug DeliveryAcne and Rosacea Treatments and Effects