ThX – a next-generation probe for the early detection of amyloid aggregates
Lisa-Maria Needham, Judith Weber, Juan A. Varela, James W. B. Fyfe, T. Dung, Catherine K. Xu, Luke Tutton, Rachel Cliffe, Benjamin Keenlyside, David Klenerman, Christopher M. Dobson, Christopher A. Hunter, Karin H. Müller, Kevin O’Holleran, Sarah E. Bohndiek, Thomas N. Snaddon, Steven F. Lee
Abstract
Introducing ThX, a next-generation ThT derivative that allows for the early detection of amyloid aggregates at the bulk and single-aggregate levels.
Topics & Concepts
Amyloid (mycology)Aggregate (composite)Derivative (finance)Amyloid βNanotechnologyAmyloid fibrilChemistryComputer scienceMaterials scienceMedicineBusinessPathologyFinanceDiseaseInorganic chemistryAlzheimer's disease research and treatmentsComputational Drug Discovery MethodsLipid Membrane Structure and Behavior