68Ga-FAPI PET/CT Distinguishes the Reactive Lymph Nodes From Tumor Metastatic Lymph Nodes in a Patient With Nasopharyngeal Carcinoma
Qihang Shang, Long Zhao, Yizhen Pang, Yifeng Yu, Haojun Chen
Abstract
ABSTRACT: Accurate clinical staging is crucial for managing nasopharyngeal carcinoma (NPC). However, false-positive finding of cervical lymph nodes in 18F-FDG PET/CT and MRI may lead to unnecessary chemotherapy for NPC. In this case, we report a patient with NPC who was incorrectly diagnosed with bilateral cervical lymph node metastases by both 18F-FDG PET/CT and MRI. Subsequent pathology results showed proliferating lymphoid cells with no signs of tumor metastasis. Interestingly, no abnormal 68Ga-FAPI uptake was observed in the nonmetastatic reactive lymph nodes. Therefore, 68Ga-FAPI PET/CT may be useful for assessment of pretreatment lymph node status in NPC.
Topics & Concepts
MedicineNasopharyngeal carcinomaLymphLymph nodeCervical lymph nodesPathologyLymphatic systemChemotherapyOncologyCarcinomaInternal medicinePrimary tumorRadiologyMetastatic carcinomaCervical lymphadenopathyMetastasisPeptidase Inhibition and AnalysisS100 Proteins and AnnexinsConnective tissue disorders research