NirA Is an Alternative Nitrite Reductase from Pseudomonas aeruginosa with Potential as an Antivirulence Target
Samuel Fenn, Jean‐Frédéric Dubern, Cristina Cigana, Maura De Simone, James Lazenby, Mario Juhas, Stephan Schwager, Irene Bianconi, Gerd Döring, Jonas Elmsley, Leo Eberl, Paul Williams, Alessandra Bragonzi, Miguel Cámara
Abstract
The emergence of widespread antimicrobial resistance has led to the need for development of novel therapeutic interventions. Antivirulence strategies are an attractive alternative to classic antimicrobial therapy; however, they require identification of new specific targets which can be exploited in drug discovery programs.
Topics & Concepts
Nitrite reductasePseudomonas aeruginosaVirulenceMutantMicrobiologyBiologyReductaseNitriteBiochemistryGeneEnzymeBacteriaNitrate reductaseGeneticsNitrateEcologyAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingPharmaceutical and Antibiotic Environmental Impacts