Proton Magnetic Resonance Spectroscopy Lactate/N-Acetylaspartate Within 48 h Predicts Cell Death Following Varied Neuroprotective Interventions in a Piglet Model of Hypoxia–Ischemia With and Without Inflammation-Sensitization
Raymand Pang, Kathryn A. Martinello, Christopher Meehan, Adnan Avdic-Belltheus, Ingran Lingam, Magdalena Sokolska, Tatenda Mutshiya, Alan Bainbridge, Xavier Golay, Nicola J. Robertson
Abstract
= 0.523). Overall, Lac/NAA correlated best with cell death and microglial activation. These data align with clinical studies demonstrating Lac/NAA superiority as an outcome predictor in neonatal encephalopathy (NE) and support its use in preclinical and clinical neuroprotection studies.
Topics & Concepts
NeuroprotectionHypoxia (environmental)InflammationIschemiaMedicineSensitizationMagnetic resonance imagingNuclear magnetic resonance spectroscopyOxygenPharmacologyChemistryInternal medicineNuclear magnetic resonanceImmunologyPhysicsOrganic chemistryRadiologyNeonatal and fetal brain pathologyNeuroscience of respiration and sleepThermal Regulation in Medicine