Electrochemical Induced Regio‐ and Stereoselective Difunctionalization of Alkynes: The Synthesis of (<i>E</i>)‐β‐Iodovinyl Sulfones
Xinghua Zhang, Danna Lu, Zhenwei Wang
Abstract
Abstract An efficient, green, and oxidant‐free electrochemical method for alkyne difunctionalization was described. Using undivided electrochemical cell for iodosulfonylation of alkynes with commercially available iodide radical (NaI), arylsulfonyl radical (ArSO 2 NHNH 2 ) sources, a variety of ( E )‐β‐iodovinyl sulfones were obtained in one‐pot with wide substrate scope, excellent regio‐ and stereoselectivity under mild and ecofriendly conditions.
Topics & Concepts
StereoselectivityChemistryAlkyneElectrochemistrySubstrate (aquarium)Combinatorial chemistryIodideRegioselectivityRadicalOrganic chemistryCatalysisElectrodeGeologyPhysical chemistryOceanographySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods