Choline supplementation attenuates experimental sepsis-associated acute kidney injury
Denise Hasson, Miki Watanabe‐Chailland, Lindsey E. Romick‐Rosendale, Adeleine Koterba, Dashiell S. Miner, Patrick Lahni, Qing Ma, Stuart L. Goldstein, Prasad Devarajan, Stephen W. Standage
Abstract
Altered choline metabolism plays a role in both human and murine sepsis-associated acute kidney injury (SA-AKI), and choline administration in experimental SA-AKI improved renal function. These findings indicate that 1) mouse models can help interrogate clinically relevant mechanisms and 2) choline supplementation may ameliorate human SA-AKI. Future research will investigate clinically the impact of choline supplementation on human renal function in sepsis and, using model systems, how choline mediates its effects.
Topics & Concepts
Acute kidney injurySepsisMedicineCholineKidneyIntensive care medicineInternal medicineNeurological Disorders and TreatmentsRenal function and acid-base balanceMetabolism and Genetic Disorders