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Inhibition of syndecan-4 reduces cartilage degradation in murine models of osteoarthritis through the downregulation of HIF-2α by miR-96-5p

Kai Zhou, Sirong He, Haoda Yu, Fuxing Pei, Zongke Zhou

2021Laboratory Investigation22 citationsDOIOpen Access PDF

Topics & Concepts

Downregulation and upregulationCartilagemicroRNAChondrocyteSmall interfering RNAOsteoarthritisMolecular biologyChemistryCancer researchMicroarray analysis techniquesBlotTransfectionCell biologyPathologyMedicineBiologyGene expressionGeneAnatomyBiochemistryAlternative medicineOsteoarthritis Treatment and MechanismsProteoglycans and glycosaminoglycans researchInflammatory mediators and NSAID effects
Inhibition of syndecan-4 reduces cartilage degradation in murine models of osteoarthritis through the downregulation of HIF-2α by miR-96-5p | Litcius