A novel pathway for stemness propagation and chemoresistance in non-small cell lung cancer via phosphorylated PKM2-loaded small extracellular vesicles
Jingyi Wang, Liu Liu, Xinyu Gao, Xiyu Liu, Yitian Dai, Zijun Mao, Shengzhe Huang, Junjian Li, Dongliang Wang, Qi Yu, Ying Han, Yu‐Dong Xu, Corrine Ying Xuan Chua, Alessandro Grattoni, Wenhui Xie, Hao Yang, Gang Huang
Abstract
This study highlights the critical role of CSC-derived sEVs in NSCLC progression and therapy resistance through the IQGAP1-mediated selective sorting of pY105-PKM2. By uncovering this novel pathway, our findings provide valuable insights into CSC pool replenishment and therapeutic resistance mechanisms in NSCLC, identifying IQGAP1 and pY105-PKM2 as promising therapeutic targets for mitigating CSC-driven malignancy and enhancing treatment efficacy.
Topics & Concepts
Extracellular vesiclesVesicleExtracellularCell biologyMicrovesiclesCancer researchPhosphorylationChemistryLung cancerCellBiologyBiochemistryMedicinePathologymicroRNAGeneMembraneExtracellular vesicles in diseaseRNA modifications and cancerMicroRNA in disease regulation