Latex and natural rubber: recent advances for biomedical applications
Karina Luzia Andrade, Heloisa Ramlow, Juliana Ferreira Floriano, Emanoelle Diz Acosta, Fabrício Luiz Faita, Ricardo Antônio Francisco Machado
Abstract
Recently, latex (NRL) and natural rubber (NR) from Hevea brasiliensis have emerged as promising biomaterials from renewable sources for biomedical applications. Although some attempts at commercial applications have been made, there is a need to comprehensively document the state-of-the-art of these biopolymers for biomedical applications and regenerative medicine. Here we present the recent advances in the development of NRL and NR as biomedical materials with potential properties including biocompatibility and biodegradability. Due to the angiogenic properties of NRL and NR, well-defined functional materials can be used for drug delivery systems (oral/transdermal), scaffolds for skin and bone regeneration, and dressings for wound healing. The incorporation of drugs, nanoparticles, cells, and others into NRL and NR polymer chains offers a wide range of applications such as dressings with antimicrobial activity and sustained release systems. Concluding remarks on the growth of these biomaterials for biomedical applications and regenerative medicine were discussed.