Structure modification and biological evaluation of indole-chalcone derivatives as anti-tumor agents through dual targeting tubulin and TrxR
Jun Yan, Yuzhu Xu, Xing Jin, Qiaoxuan Zhang, Feng Ouyang, Liqiao Han, Min Zhan, Xingshu Li, Baoxia Liang, Xianzhang Huang
Topics & Concepts
ChemistryCancer cellChalconeTubulinApoptosisCell cycle checkpointIn vivoBiochemistryDrug discoveryCancerThioredoxinCell cycleCancer researchMicrotubuleCell biologyStereochemistryEnzymeBiologyGeneticsBiotechnologyRedox biology and oxidative stressSynthesis and Biological EvaluationSynthesis and biological activity