Litcius/Paper detail

Structure modification and biological evaluation of indole-chalcone derivatives as anti-tumor agents through dual targeting tubulin and TrxR

Jun Yan, Yuzhu Xu, Xing Jin, Qiaoxuan Zhang, Feng Ouyang, Liqiao Han, Min Zhan, Xingshu Li, Baoxia Liang, Xianzhang Huang

2021European Journal of Medicinal Chemistry45 citationsDOI

Topics & Concepts

ChemistryCancer cellChalconeTubulinApoptosisCell cycle checkpointIn vivoBiochemistryDrug discoveryCancerThioredoxinCell cycleCancer researchMicrotubuleCell biologyStereochemistryEnzymeBiologyGeneticsBiotechnologyRedox biology and oxidative stressSynthesis and Biological EvaluationSynthesis and biological activity