Intracellular location matters: rationalization of the anti-inflammatory activity of a manganese(<scp>ii</scp>) superoxide dismutase mimic complex
Émilie Mathieu, Anne-Sophie Bernard, Elodie Quévrain, Martha Zoumpoulaki, Sébastien Iriart, Caroline Lung-Soong, Barry Lai, Kadda Medjoubi, Lucas P. Henry, Sounderya Nagarajan, Florent Poyer, Andreas Scheitler, Ivana Ivanović‐Burmazović, Sergio Marco, Andréa Somogyi, Philippe Seksik, Nicolas Delsuc, Clotilde Policar
Abstract
A conjugate of a Mn-based superoxide dismutase mimic with a Re-based multimodal probe 1[combining low line] was studied in a cellular model of oxidative stress. Its speciation was investigated using Re and Mn X-fluorescence. Interestingly, 1[combining low line] shows a distribution different from its unconjugated analogue but a similar concentration in mitochondria and a similar bioactivity.
Topics & Concepts
Superoxide dismutaseIntracellularChemistrySuperoxideOxidative stressManganeseMitochondrionBiochemistryRationalization (economics)Cell biologyEnzymeBiologyEpistemologyOrganic chemistryPhilosophyMetal-Catalyzed Oxygenation MechanismsLanthanide and Transition Metal ComplexesElectron Spin Resonance Studies