Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation
Daisuke Aibara, Shogo Takahashi, Tomoki Yagai, Donghwan Kim, Chad Brocker, Moshe Levi, Kimihiko Matsusue, Frank J. Gonzalez
Abstract
after PPARA activation, and suppressed hepatocyte hyperproliferation. These results demonstrate that the PPARA-E2F8-UHRF1-CDH1 axis causes epigenetic regulation of hepatocyte proliferation.
Topics & Concepts
Wnt signaling pathwayCell biologyPeroxisome proliferator-activated receptorHepatocytePsychological repressionNuclear receptorChemistryGene knockdownPeroxisome proliferator-activated receptor alphaCancer researchBiologySignal transductionGene expressionReceptorBiochemistryTranscription factorGeneIn vitroEpigenetics and DNA MethylationPeroxisome Proliferator-Activated ReceptorsCancer-related gene regulation