miR-181a, delivered by hypoxic PTC-secreted exosomes, inhibits DACT2 by downregulating MLL3, leading to YAP-VEGF-mediated angiogenesis
Yingxue Wang, Aiying Cen, Yu‐Xian Yang, Huilin Ye, Jiaying Li, Shiliang Liu, Lei Zhao
Abstract
, which was reversed by hypoxic exosomal miR-181a inhibitor. In conclusion, exosomal miR-181a from hypoxic PTC cells promotes tumor angiogenesis and growth through MLL3 and DACT2 downregulation, as well as VEGF upregulation.
Topics & Concepts
AngiogenesisMicrovesiclesCancer researchDownregulation and upregulationVascular endothelial growth factorMetastasismicroRNAExosomePapillary thyroid cancerThyroid cancerChemistryCell biologyBiologyMedicineCancerInternal medicineBiochemistryVEGF receptorsGeneExtracellular vesicles in diseaseCancer-related molecular mechanisms researchCircular RNAs in diseases