A disulfide-induced supra-amphiphilic co-assembly for glycosylated pro-drug-photosensitizer nanoparticles in combination therapies
Wenjuan Jin, Zelong Chen, Senyu Yang, Yun Qu, Yuxin Pei, Zhichao Pei
Abstract
A disulfide-induced supra-amphiphilic co-assembly strategy for hydrophobic drug co-delivery in combination therapies was proposed based on a disulfide bond containing hydrophobic pro-drug-photosensitizer (BG) and a hydrophilic/targeting dimer lactose molecule (Lac-SS-Lac). The anti-tumor efficiency was significantly enhanced by the combination therapies of epidermal growth factor receptor (EGFR) targeted therapy and phototherapy in EGFR-positive and/or galectin overexpressed tumors.
Topics & Concepts
PhotosensitizerAmphiphileChemistryDisulfide bondDrugEpidermal growth factor receptorDrug deliveryNanoparticleBiophysicsCombinatorial chemistryReceptorBiochemistryPharmacologyNanotechnologyOrganic chemistryCopolymerMaterials scienceMedicinePolymerBiologyNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesRNA Interference and Gene Delivery