Post-Cardiac Arrest: Mechanisms, Management, and Future Perspectives
Taline Lazzarin, Carolina Rodrigues Tonon, Danilo Martins, Edson Luiz Fávero, Thiago Dias Baumgratz, Filipe Welson Leal Pereira, Victor Rocha Pinheiro, Raquel Simões Ballarin, Diego Aparecido Rios Queiróz, Paula S. Azevedo, Bertha Furlan Polegato, Marina Politi Okoshi, Leonardo Antônio Mamede Zornoff, Sérgio Alberto Rupp de Paiva, Marcos Ferreira Minicucci
Abstract
Cardiac arrest is an important public health issue, with a survival rate of approximately 15 to 22%. A great proportion of these deaths occur after resuscitation due to post-cardiac arrest syndrome, which is characterized by the ischemia-reperfusion injury that affects the role body. Understanding physiopathology is mandatory to discover new treatment strategies and obtain better results. Besides improvements in cardiopulmonary resuscitation maneuvers, the great increase in survival rates observed in recent decades is due to new approaches to post-cardiac arrest care. In this review, we will discuss physiopathology, etiologies, and post-resuscitation care, emphasizing targeted temperature management, early coronary angiography, and rehabilitation.