Differential T cell immune responses to deamidated adeno-associated virus vector
So Jin Bing, Sune Justesen, Wells W. Wu, Abdul Mohin Sajib, Stephanee Warrington, Alan N. Baer, Stephan Thorgrimsen, Rong‐Fong Shen, Ronit Mazor
Abstract
HLA binding assays showed differential binding to the deamidated or non-deamidated peptides in some HLA alleles. This study provides critical attributes to vector-immune-mediated responses, as AAV deamidation can impact the immunogenicity, safety, and efficacy of AAV-mediated gene therapy in some patients.
Topics & Concepts
Immune systemAdeno-associated virusVector (molecular biology)VirusBiologyVirologyDifferential (mechanical device)CellImmunologyPhysicsGeneticsGeneRecombinant DNAThermodynamicsVirus-based gene therapy researchCAR-T cell therapy researchImmunotherapy and Immune Responses