Direct and Chemoselective Electrophilic Monofluoromethylation of Heteroatoms (<i>O</i>-, <i>S-</i>, <i>N</i>-, <i>P</i>-, <i>Se</i>-) with Fluoroiodomethane
Raffaele Senatore, Monika Malik, Markus Spreitzer, Wolfgang Hölzer, Vittorio Pace
Abstract
the requirement for fluoromethylating agents with no immediate access. The high-yielding methodology was successfully applied to a variety of nucleophiles including a series of drugs currently in the market.
Topics & Concepts
HeteroatomNucleophileElectrophileChemistryCombinatorial chemistryDe factoSeries (stratigraphy)Organic chemistryRing (chemistry)CatalysisLawPolitical sciencePaleontologyBiologyFluorine in Organic ChemistryInorganic Fluorides and Related Compounds