Rhythm of the Night (and Day): Predictive Metabolic Modeling of Diurnal Growth in <i>Chlamydomonas</i>
Alexander J. Metcalf, Nanette Boyle
Abstract
We have developed the first transient metabolic model for diurnal growth of algae based on experimental data and capable of predicting phenotype from genotype. This model enables us to evaluate the impact of genetic and environmental changes on the growth, biomass composition and intracellular fluxes of the model green alga, Chlamydomonas reinhardtii. The availability of this model will enable faster and more efficient design of cells for production of fuels, chemicals, and pharmaceuticals.
Topics & Concepts
Chlamydomonas reinhardtiiTranscriptomeBiologyChlamydomonasBiomass (ecology)Circadian rhythmFlux (metallurgy)Diurnal cyclePhenotypePhotosynthesisMutantModel organismProductivityBiological systemEcologyGeneticsGeneBotanyChemistryAtmospheric sciencesGene expressionPhysicsEconomicsOrganic chemistryNeuroscienceMacroeconomicsAlgal biology and biofuel productionMicrobial Metabolic Engineering and BioproductionGene Regulatory Network Analysis