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Combination of encorafenib and binimetinib followed by ipilimumab and nivolumab versus ipilimumab and nivolumab in patients with advanced melanoma with BRAFV600E or BRAFV600K mutations (EBIN): an international, open-label, randomised, controlled, phase 2 study

Caroline Robert, Michal Kiciński, Caroline Dutriaux, Émilie Routier, Anne-Sophie Govaerts, Emanuel Bührer, Eve‐Marie Neidhardt, Xavier Durando, Barouyr Baroudjian, Philippe Saïag, Caroline Gaudy‐Marqueste, Paolo A Ascierto, Ana Arance, Michelangelo Russillo, Jean‐Luc Perrot, Laurent Mortier, F. Aubin, Stéphane Dalle, Florent Grange, Eva Muñoz‐Couselo, Sorilla Mary-Prey, Mona Amini‐Adlé, Sandrine Mansard, Célèste Lebbé, Elisa Funck‐Brentano, S. Monestier, Alexander Eggermont, Felix Boakye Oppong, Leen Wijnen, Bastian Schilling, M. Mandala, Paul Lorigan, Alexander C. J. van Akkooi

2025The Lancet Oncology10 citationsDOI

Topics & Concepts

NivolumabIpilimumabMedicineOpen labelMelanomaOncologyInternal medicineRandomized controlled trialImmunotherapyCancer researchCancerMelanoma and MAPK PathwaysCancer Immunotherapy and BiomarkersCutaneous Melanoma Detection and Management
Combination of encorafenib and binimetinib followed by ipilimumab and nivolumab versus ipilimumab and nivolumab in patients with advanced melanoma with BRAFV600E or BRAFV600K mutations (EBIN): an international, open-label, randomised, controlled, phase 2 study | Litcius