Activity of Omadacycline in Rat Methicillin-Resistant Staphylococcus aureus Osteomyelitis
Melissa J. Karau, Suzannah M. Schmidt-Malan, Scott A. Cunningham, Jayawant N. Mandrekar, Bobbi S. Pritt, Tiffany R. Keepers, Alisa W. Serio, Surya Chitra, Robin Patel
Abstract
CFU/g for saline-, rifampin-, vancomycin-, and omadacycline-treated animals, respectively. Omadacycline or vancomycin administered with rifampin yielded no detectable MRSA. Omadacycline administered with rifampin deserves evaluation in humans as a potential treatment for osteomyelitis.
Topics & Concepts
Staphylococcus aureusMedicineMicrococcaceaeOsteomyelitisMicrobiologyAntibioticsVancomycinAntibacterial agentStaphylococcusStaphylococcal infectionsMeticillinDrug resistancePharmacologyMethicillin-resistant Staphylococcus aureusRifampicinInternal medicineSurgeryOsteitisBacteriaGastroenterologyOrthopedic Infections and TreatmentsAntimicrobial Resistance in StaphylococcusAntibiotics Pharmacokinetics and Efficacy