Suppression on allergic airway inflammation of dehulled adlay (<i>Coix lachryma-jobi</i>L. var.<i>ma-yuen</i>Stapf) in mice and anti-degranulation phytosterols from adlay bran

Abstract

-glucopyranoside and β-sitosterol inhibited β-hexosaminidase release from A23187-stimulated RBL-2H3 cells with percentages of 54.1%, 52.0% and 48.5%, respectively, at 50 μM. In addition, β-sitosterol reduced immunoglobulin (Ig)E-stimulated degranulation on RBL-2H3 cells in a dose-dependent manner. The phytosterols were the predominant components based on gas chromatography (GC) analysis. This is the first study to demonstrate that DA suppressed OVA/Mch-induced acute airway inflammation. The phytosterols in AB showed significant anti-degranulation activities, and may be regarded as the indicative components of AB for anti-allergy effects.

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