Oxidative stress and ovarian aging: from cellular mechanisms to diagnostics and treatment
Omar F Ammar, Claudia Massarotti, M Mincheva, Kashish Sharma, George Liperis, Sonia Herraiz, Aida Rodríguez‐Nuevo, Filippo Zambelli, Bettina P. Mihalas, Juan J Fraire-Zamora
Abstract
The December ESHRE Journal Club discussion focused on a study by Smits et al. (2023), the cellular and molecular implications of oxidative stress on oocyte aging, the factors that impair oocyte quality besides age, and the potential therapeutic strategies to mitigate oxidative stress and mitochondrial dysfunction in oocytes of advanced maternal age.AMA, advanced maternal age; GV, germinal vesicle oocyte; MI, metaphase I oocyte; ROS, reactive oxygen species; TCA, tricarboxylic acid cycle.
Topics & Concepts
Oxidative stressMedicineInternal medicineGenomics, phytochemicals, and oxidative stressRedox biology and oxidative stressGlutathione Transferases and Polymorphisms