Overall Survival Rate of Patients With Triglyceride Deposit Cardiomyovasculopathy
Ken‐ichi Hirano, Hideyuki Miyauchi, Yusuke Nakano, Yuko Kawaguchi, Satomi Okamura, Yuki Nishimura, Tomohiro Onishi, Shinichiro Fujimoto, Tomomi Yamada, Tetsuya Amano
Abstract
Triglyceride deposit cardiomyovasculopathy (TGCV) is an emerging, rare cardiovascular disorder (Orphanet ORPHA code: 565612) first reported in 2008 in patients requiring cardiac transplantation. 1 TGCV is caused by defective intracellular lipolysis of triglyceride (TG) leading to heart failure and diffuse narrowing atherosclerosis with TG deposition.Since 2009, the Japan TGCV study group has elucidated its pathophysiology and developed diagnostic methods and specific treatments as a part of a governmental rare disease project.
Topics & Concepts
TriglycerideGeologyEnvironmental scienceGeochemistryInternal medicineMedicineCholesterolMitochondrial Function and PathologyCardiovascular Function and Risk FactorsAdipose Tissue and Metabolism