A tumor-suppressive circular RNA mediates uncanonical integrin degradation by the proteasome in liver cancer
Liang Shi, Boqiang Liu, Dandan Shen, Peijian Yan, Yanan Zhang, Yuanshi Tian, Lidan Hou, Guangyi Jiang, Yinxin Zhu, Yuelong Liang, Xiao Liang, Bo Shen, Hong Yu, Yan Zhang, Yifan Wang, Xing Guo, Xiujun Cai
Abstract
integrin). Mass spectrometry and biochemical evidence demonstrate that circPABPC1 directly links ITGB1 to the 26S proteasome for degradation in a ubiquitination-independent manner. Our data have revealed an uncanonical route for integrin turnover and a previously unidentified mode of action for circRNAs in HCC that can be harnessed for anticancer treatment.
Topics & Concepts
ProteasomeLiver cancerDegradation (telecommunications)IntegrinCancerCancer researchRNACell biologyChemistryMedicineBiologyInternal medicineBiochemistryComputer scienceCellGeneTelecommunicationsCircular RNAs in diseasesinterferon and immune responsesRNA Research and Splicing