The Proton of Alcohols as Hydrogen Source in Diboron-Mediated Nickel-Catalyzed Asymmetric Transfer Hydrogenation of Cyclic <i>N</i>-Sulfonyl Imines
Bo Wu, Yu-Qing Bai, Xiaoqing Wang, Wen‐Jun Huang, Yong‐Gui Zhou
Abstract
The proton of alcohols as the sole hydrogen source in diboron-mediated nickel-catalyzed asymmetric transfer hydrogenation of cyclic N -sulfonyl imines has been developed, providing the chiral cyclic sulfamidates in excellent enantioselectivities. The mechanistic investigations suggested that the proton of alcohols could be activated by tetrahydroxydiboron to form active nickel hydride species.
Topics & Concepts
ChemistryNickelCatalysisHydrideSulfonylHydrogenProtonOrganic chemistryMedicinal chemistryCombinatorial chemistryQuantum mechanicsPhysicsAlkylAsymmetric Hydrogenation and CatalysisCarbon dioxide utilization in catalysisOrganoboron and organosilicon chemistry