Glucose induces metabolic reprogramming in neutrophils during type 2 diabetes to form constitutive extracellular traps and decreased responsiveness to lipopolysaccharides
Manjunath B. Joshi, Rayees Ahamed, Mangala Hegde, Aswathy S Nair, Lingadakai Ramachandra, Kapaettu Satyamoorthy
Topics & Concepts
Polyol pathwayNeutrophil extracellular trapsAldose reductaseInnate immune systemNADPH oxidaseCarbohydrate metabolismExtracellularMetabolismInflammationBiologyBiochemistryType 2 diabetesGlycolysisReactive oxygen speciesChemistryEndocrinologyDiabetes mellitusImmunologyEnzymeReceptorNeutrophil, Myeloperoxidase and Oxidative MechanismsNitric Oxide and Endothelin EffectsImmune cells in cancer