A Perspective on Roles Played by Immunosenescence in the Pathobiology of Alzheimer's Disease
Yan Zhao, Junkun Zhan, You‐Shuo Liu
Abstract
Alzheimer's disease (AD) is a chronic progressive neurodegenerative disorder. Aging is the most significant risk factor for late-onset AD. The age-associated changes in the immune system are termed immunosenescence. A close connection between immunosenescence and AD is increasingly recognized. This article provides an overview of immunosenescence and evidence for its role in the pathogenesis of AD and possible mechanisms as well as the outlook for drug development.
Topics & Concepts
ImmunosenescenceDiseaseMedicinePerspective (graphical)Alzheimer's diseasePathogenesisImmunologyImmune systemInternal medicineArtificial intelligenceComputer scienceTryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments