Molecular signatures and cellular diversity during mouse habenula development
Lieke L. van de Haar, Danai Riga, Juliska E. Boer, Oxana Garritsen, Youri Adolfs, Thomas E. Sieburgh, Roland E. van Dijk, Kyoko Watanabe, Nicky C.H. van Kronenburg, Mark H. Broekhoven, Daniëlle Posthuma, Frank J. Meye, Onur Başak, R. Jeroen Pasterkamp
Abstract
habenula neurons. Finally, we show how comparison of single-cell transcriptional profiles and GWAS data links specific developing habenular subtypes to psychiatric disease. Together, our study begins to dissect the mechanisms underlying habenula neuron subtype-specific development and creates a framework for further interrogation of habenular development in normal and disease states.
Topics & Concepts
HabenulaNeuroscienceBiologyEmbryonic stem cellNeuronCell typeEpigenesisCellCentral nervous systemGeneticsGeneGene expressionDNA methylationNeurobiology and Insect Physiology ResearchHippo pathway signaling and YAP/TAZCell Image Analysis Techniques