PTPN22 phosphorylation acts as a molecular rheostat for the inhibition of TCR signaling
Shen K. Yang, Mattias N. D. Svensson, Nathaniel H. O. Harder, Wan‐Chen Hsieh, Eugenio Santelli, William B. Kiosses, James J. Moresco, John R. Yates, Charles C. King, Lin Liu, Stephanie M. Stanford, Nunzio Bottini
Abstract
mediates a reciprocal regulation of PTPN22 stability versus translocation to TCR signaling complexes by CSK-dependent and CSK-independent mechanisms.
Topics & Concepts
PhosphorylationT-cell receptorCell biologySignal transductionBiologyChemistryGeneticsT cellImmune systemProtein Tyrosine PhosphatasesGalectins and Cancer BiologyEndoplasmic Reticulum Stress and Disease